Product Description
PUGNAc is a 1,5-hydroximolactone, acting as an inhibitor of a variety of N-acetylhexosaminidases. It was long thought that increased levels of O-GlcNAc in human cells lead to Type II diabetes. O-GlcNAc levels were artificially raised with PUGNAc, which inhibits O-GlcNAcase, a beta-exo-N-acetylhexosaminidase which cleaves beta-O-linked-N-acetylglucosamine residues from glycoproteins. As a result of this inhibition, a type II diabetic phenotype was observed. Recent pharmacological studies using a more selective O-GlcNAcase inhibitor did not see this effect. However, genetic manipulation of O-GlcNAc levels is consistent with the effects observed by PUGNAc, namely insulin resistance upon elevation of O-GlcNAc levels.
Exceptional Purity and StabilityPUGNAc extrapure, 95% is manufactured to meet rigorous quality standards, ensuring a purity of at least 95%. The product remains stable under the recommended storage conditions of -20C, protected from light and moisture. Its crystalline, odorless powder form guarantees ease of handling and reproducibility in laboratory environments, making it a preferred choice for researchers in enzyme inhibition and biochemical studies.
Versatile Applications in ResearchDesigned for laboratory use, PUGNAc extrapure greatly facilitates research in enzyme inhibition and related biochemical fields. Its high solubility in DMSO and ethanol expands its application range, allowing for flexibility in various experimental protocols. The reagent's non-poisonous, non-hazardous nature ensures safe handling when standard laboratory precautions are followed, benefitting both seasoned scientists and laboratory newcomers.
FAQ's of PUGNAc extrapure, 95%:
Q: How should PUGNAc extrapure, 95% be stored to maintain its stability and potency?
A: PUGNAc extrapure, 95% should be stored at -20C, in a dry environment, and protected from light. Adhering to these conditions preserves its stability and extends the product's shelf life up to 24 months.
Q: What are the primary uses of PUGNAc extrapure, 95% in the laboratory?
A: The compound is widely used as a chemical reagent for enzyme inhibition research, as well as other general laboratory studies related to biochemical assays and investigations.
Q: When is a cold pack needed for shipping PUGNAc extrapure, 95%?
A: Shipping is typically conducted at ambient conditions, but a cold pack can be provided upon request or if specified due to environmental or regional requirements to maintain product integrity.
Q: Where can I obtain a Certificate of Analysis for PUGNAc extrapure, 95%?
A: A Certificate of Analysis is available upon request from the supplier, providing detailed batch information and quality assurance data for your records.
Q: What precautions should be followed when handling PUGNAc extrapure, 95%?
A: While the product is non-hazardous and non-poisonous for laboratory use, it is recommended to use standard safety measures, including gloves and eye protection, to avoid contact and maintain safe laboratory practices.
Q: What are the benefits of choosing PUGNAc extrapure, 95% over other grades?
A: PUGNAc extrapure, 95% offers proven purity and stability, with stringent quality control ensuring reliability for sensitive research applications, especially enzyme inhibition studies and other advanced biochemical experiments.