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PUGNAc extrapure, 95%

PUGNAc extrapure, 95%

42 USD ($)/Milligram

Product Details:

  • HS Code 29420090
  • Chemical Name PUGNAc
  • CAS No 132489-69-1
  • Purity(%) 95
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PUGNAc extrapure, 95% Price And Quantity

  • 5 Milligram
  • 42 USD ($)/Milligram

PUGNAc extrapure, 95% Product Specifications

  • 95
  • 29420090
  • 132489-69-1
  • PUGNAc

PUGNAc extrapure, 95% Trade Information

  • Mumbai International Airport
  • Cash on Delivery (COD) Cash Advance (CA) Letter of Credit (L/C) Paypal Western Union Letter of Credit at Sight (Sight L/C) Delivery Point (DP) Cash Against Delivery (CAD) Telegraphic Transfer (T/T) Days after Acceptance (DA) Cash in Advance (CID) Cheque
  • 1000 Milligram Per Month
  • 5 Days
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Product Description

PUGNAc is a 1,5-hydroximolactone, acting as an inhibitor of a variety of N-acetylhexosaminidases. It was long thought that increased levels of O-GlcNAc in human cells lead to Type II diabetes. O-GlcNAc levels were artificially raised with PUGNAc, which inhibits O-GlcNAcase, a beta-exo-N-acetylhexosaminidase which cleaves beta-O-linked-N-acetylglucosamine residues from glycoproteins. As a result of this inhibition, a type II diabetic phenotype was observed. Recent pharmacological studies using a more selective O-GlcNAcase inhibitor did not see this effect. However, genetic manipulation of O-GlcNAc levels is consistent with the effects observed by PUGNAc, namely insulin resistance upon elevation of O-GlcNAc levels.
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