The coronavirus disease 2019(COVID-19) pandemic is a major global threat. With no effective antiviral drugs, the repurposing of many currently available drugs has been considered.One such drug is Ivermectin, an FDA-approved anti parasitic agent that has been shown to exhibit antiviral activity against a broad range of viruses. Recent Studies have suggested that Ivermectin inhibits the replication of severe acuterespiratory syndrome coronavirus 2 (SARS-CoV-2),thus suggesting its potential for use against COVID-19. This review has summarized the evidence derived fromdocking and modeling analysis, in vitro and in vivo studies, and results fromnew investigational drug protocols, as well as clinical trials, if available,which will be effective in supporting the prospective use of Ivermectin as an alternative treatment for COVID-19.Keywords: SARS-CoV-2; COVID-19; Ivermectin;treatment; antiviral.

Quadruple Therapy includes Ivermectin 12 mg one dose, Doxycycline100 mg once a day for four days, Zinc 50 mg once a day for four days and Vitamin D3 once a week. Ivermectin, Doxycycline and Zinc are to be repeatedevery 14 days and Vitamin D3 every week with blood levels monitored. Thesynergistic effect of these medicine acts to prevent viral multiplication andalso stop the virus from entering human cells.

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